Panos N. Papapanou
Periodontitis and cardiovascular disease: an update on the link between periodontal infection/inflammation and atherogenesis
- Professor of Dental Medicine, Director of the Division of Periodontics, and Chairman of the Section of Oral, Diagnostic and Rehabilitation Sciences, at the College of Dental Medicine, Columbia University in New York
- He has received DDS degrees from the University of Athens, Greece, and Columbia University, a PhD from Göteborg University, Sweden, and post-doctoral training at the Forsyth Institute, Boston
- His research encompasses studies of the epidemiology of periodontal disease, the assessment of microbial and host-derived risk factors, the pathobiology of periodontitis and its role in general health
- He is the recipient of several international awards including the 2017 Distinguished Scientist Award for Basic Research in Periodontal Disease from the IADR
Nationality: Greece
Scientific areas: Oral health | General health
14 of november, from 15h15 until 16h00
Auditório B
Conference summary
Periodontal disease is a non-communicable disease of high prevalence globally. According to recent data, severe forms of periodontitis affect approximately 10-15% of the adult population. The disease is associated with bacterial dysbiosis at the dento-gingival niche and elicits a local inflammatory response that results in loss of connective tissue attachment, alveolar bone loss and, ultimately, tooth loss. Importantly, periodontitis is associated with transient bacteremias, elevated systemic inflammation and vascular endothelial activation. A 2012 Scientific Statement of the American Heart Association that summarized findings from epidemiologic and experimental studies conducted over the past 30 years concluded that the association between periodontal infection/inflammation and atherosclerotic vascular disease is independent of known confounders. This conclusion was corroborated and further extended by a 2019 Consensus Report developed by the European Federation of Periodontology and the World Heart Federation. The lecture will summarize key elements of the biological plausibility of the link between periodontitis and atherosclerotic vascular disease, will critically assess recent epidemiologic data from both association and intervention studies, will highlight existing gaps in knowledge, and will articulate an appropriate message to the public on the interrelation of the two diseases.
Scientific sponsor