Mariano Sanz
Periodontitis and other systemic disease associations - rheumatoid arthritis, Alzheimer's disease and cancer
- MD – Degree-Universidad Complutense of Madrid (MD)
- Specialist in Stomatology. Universidad Complutense de Madrid (DDS)
- Specialist in.Periodontology. University of California, Los Angeles (UCLA)
- Doctor en Medicine (PhD degree). Universidad Complutense de Madrid (DrMed)
- Honorary Doctorate Degree by the University of Buenos Aires (Argentina) (DrHC)
- Honorary Doctorate Degree by the University of Gothenburg (Sweden) (DrHC)
- Honorary Doctorate Degree by the University of Coimbra (Portugal) (DrHC)
- Honorary Doctorate Degree by the University of San Sebastian in Santiago de Chile (DrHC)
- Professor of Periodontology. Universidad Complutense de Madrid
- Professor II University of Oslo
- Director of the Graduate Programme “Master in Periodontology”. Universidad Complutense de Madrid
- Chairman of the Workshop Committee of the European Federation of Periodontology
- President of the Osteology Foundation
- Patron of the Spanish Society of Periodontology Foundation
- Past – Dean of the Faculty of Odontology. Universidad Complutense de Madrid
- Past – President of the European Conference of Dental Deans (ADEE)
- Past-Secretary General of the European Federation of Periodontology (EFP)
- Past-President of the Spanish Society of Periodontology (SEPA)
- Past -President of the Pan European Region (PER) of the International Association for Dental Research (IADR-CED)
- Associate Editor of the Scientific Journal Evidence-Based Dental Practice and Journal of Clinical Periodontology
- Has published more than 250 scientific articles and book chapters in Periodontology, Implant Dentistry and Dental Education
Nationality: Spain
Scientific areas: Oral health | General health
14 of november, from 17h30 until 19h00
Auditório B
Conference summary
Periodontitis has demonstrated significant epidemiological association with different systemic diseases, being the most studied cardiovascular diseases, diabetes and adverse pregnancy outcomes. The biological plausibility of these associations has been elucidated mainly through mechanism based on the rise of systemic inflammation as consequence of periodontitis and the possible passage of bacteria to the blood flow (bacteremia) and colonisation at distant sites.
In the last 10 years, however, other systemic diseases have also shown significant associations with periodontitis and other specific mechanisms have been studied and discussed. Among these rheumatoid arthritis has been associated due to the capacity of the periodontal pathogen Porphyromona gingivalis to citrullinate host proteins and develop autoantibodies. Similarly these bacteria have shown capability to travel beyond the hematoencephalic barrier and cause local inflammation, hence linking periodontitis to Alzheimer disease.
Similarly, some oral bacteria have specific tropisms and through molecular mimicry mechanisms may promote specific oncogenes and through these mechanisms linking periodontitis to cancer, mainly colorectal and pancreatic. In this presentation all these mechanisms will be discussed together with the public health implications of these associations.
Scientific sponsor
EXAKTUS